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© Copyright 2012 Chemical Biology Ventures Limited. All Rights Reserved. Registered in England & Wales number 7968150. Registered office: 30 Upper High Street, Thame, Oxfordshire, OX9 3EZ. Address for correspondence: 123 Alexander Close, Abingdon, Oxfordshire, OX14 1XD

Translation into Clinical studies

Experimental medicine

Contact CBV


Tel: +44 (0) 1235 532481

Mob:          07836 554231


Preparing for First-in-Man studies is an exciting phase of a project. It is a huge value inflection point and bring the reality of the creation of a new medicine so much closer. CBV has experience in achieving this important project milestones & can provide the guidance you may need.


Clinical evaluation of BB-10010, an engineered chemokine



To transition into clinical evaluation with aggressive timelines & budget



Identify gobal opinion leaders, to meet and to select key clinical partners to lead centres through Phase I and Phase II international studies.


Reference Link:


Marshall E., Lord BI., Howell AH., Powles R., Hunter MG., Edwards M, Wood LM., Czaplewski LG., Puttick R., Warington S., Boyce M., Testa N., Dexter TM., Lord BI., Millar A. Clinical effects of human MIP�1alpha (LD78) administration to humans: A phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant BB-10010. European Journal of Cancer 34(7), 1023-1029, 1998.


Czaplewski LG., McCourt M., Hunter MG., Lord BI., Millar A., Wood LM.  Engineering, biology and clinical development of hMIP-1 alpha in Chemokines in Human Disease (Hebert C., ed.) Humana Press Inc, Totowa NJ. 1998.


Clemons MJ., Marshall E., Durig J., Watanabe K., Howell A., Miles D., Earl H., Kiernan J., Griffiths A., Towlson K., DeTakats P., Testa NG., Dougal M., Hunter MG., Wood LM., Czaplewski LG., Millar A., Dexter TM., Lord BI. A randomised phase-II study of BB-10010 (Macrophage inflammatory protein-1 alpha with advanced breats cancer receiving 5-FU, adriamycin and cyclophosphamide (FAC) chemotherapy.  Blood 92, 1532-1540, 1998.

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