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© Copyright 2012 Chemical Biology Ventures Limited. All Rights Reserved. Registered in England & Wales number 7968150. Registered office: 30 Upper High Street, Thame, Oxfordshire, OX9 3EZ. Address for correspondence: 123 Alexander Close, Abingdon, Oxfordshire, OX14 1XD

Core expertise

Bacterial genetics

Contact CBV


Tel: +44 (0) 1235 532481

Mob:          07836 554231


Bacterial  genetics is a core expertise with experience across Streptomyces, Bacillus, Staphylococci, E. coli & others. From strain improvement, product expression or target validation, CBV can provide expert advice to aid delivery of project objectives.


Cryptic genomic redundancy identified by combinatorial gene knockout of potential complementary active sites



To characterise genome redundancy & to identify potential synthetic lethal gene combinations



Use bio-informatics to identify potential active sites present in two or more proteins in a genome eg related families & then to systematically knockout family members individually & in combination to reveal previously cryptic complementary protein functions.


Reference Link:

Thomaides HB, Davison EJ, Burston L, Johnson H, Brown DR, Hunt AC, Errington J, Czaplewski L. Essential bacterial functions encoded by gene pairs. J. Bact. 189, 591-601, 2007

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