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Bacterial genetics is a core expertise with experience across Streptomyces, Bacillus, Staphylococci, E. coli & others. From strain improvement, product expression or target validation, CBV can provide expert advice to aid delivery of project objectives.
Cryptic genomic redundancy identified by combinatorial gene knockout of potential complementary active sites
To characterise genome redundancy & to identify potential synthetic lethal gene combinations
Use bio-informatics to identify potential active sites present in two or more proteins in a genome eg related families & then to systematically knockout family members individually & in combination to reveal previously cryptic complementary protein functions.
Thomaides HB, Davison EJ, Burston L, Johnson H, Brown DR, Hunt AC, Errington J, Czaplewski L. Essential bacterial functions encoded by gene pairs. J. Bact. 189, 591-601, 2007