Medicinal chemistry

The engine of chemical biology

Whether making chemical probes or new drugs, managing efficient chemistry programmes is a key component of success. Effectively bridging the disciplines of biology & chemistry is the core of CBVs
service. Providing project review & mentoring to maximise progress versus activity; to present alternative views to work through & around problems & to support project outsourcing & progression into scale-up, preclinical development & beyond, CBV can add value & pace to your portfolio.

Lloyd Czaplewski, a biologist by training and a Fellow of the Royal Society of Chemistry , recognising his ability to work across disciplines, has a strong track record of delivering successful projects, generating & managing intellectual property. and has worked with a variety of synthetic and natural product scaffolds including imidazolopyridines, triazolopyridines, benzothiazoles, benzamides, aminocoumarins & various lactams. He has directed projects based on structure-based design, traditional medicinal chemistry and novel approaches driven by neural net technology. His inputs including iterative compound design, route development to the kilo scale & selection of service providers & collaborators have had direct impact on project progression and delivery.

DNA-I

Compounds selected from published patents eg US 2009/0197877 & East et al

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