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Core expertise
Bacterial genetics
Contact CBV
Bacterial genetics is a core expertise with experience across Streptomyces, Bacillus, Staphylococci, E. coli & others. From strain improvement, product expression or target validation, CBV can provide expert advice to aid delivery of project objectives.
Example:
Cryptic genomic redundancy identified by combinatorial gene knockout of potential complementary active sites
Problem:
To characterise genome redundancy & to identify potential synthetic lethal gene combinations
Solution:
Use bio-informatics to identify potential active sites present in two or more proteins in a genome eg related families & then to systematically knockout family members individually & in combination to reveal previously cryptic complementary protein functions.
Reference Link:
Thomaides HB, Davison EJ, Burston L, Johnson H, Brown DR, Hunt AC, Errington J, Czaplewski L. Essential bacterial functions encoded by gene pairs. J. Bact. 189, 591-601, 2007